Enzyme Engineering and Modification

Creative Enzymes provides the enzyme engineering and modification service to help clients with the increasing needs in improving enzyme activity and properties and creating the perfect biocatalyst for a new reaction. Creative Enzymes is one of the few companies that provide solutions to such challenging tasks. After many years in serving companies and research institutes, we have demonstrated high reliability of our services.

Specialized expertise and resources Powerful computational modeling
Construction of large mutant libraries High throughput screening
Results analysis

Enzymes engineering and modification workflow


Creative Enzymes has strong ability to offer one-stop service for enzyme engineering and modification. Our services are listed below:

Services Price
Enzyme Engineering Directed evolution Get a quote
Rational design
De novo enzyme engineering
Site-directed mutagenesis
Random mutagenesis and DNA shuffling
Phage display and mRNA display
Incorporation of unnatural amino acids
Enzyme Modification Immobilization Get a quote
Covalent modifications (such as PEGylation)
Enzyme labelling
Synthetic Enzymes Synzymes Get a quote


Q1: Why should I modify my enzyme?

The existing enzymes can go through certain structural alterations and hence, the resulted function and catalytic activity allow new catalyzed pathways of reactions. In addition, modification could also enhance biochemical properties, pharmacokinetics, and stability. Enzymes can be physically modified in immobilization and encapsulation. Researchers also extent naturally occurring chemical reactions of enzymes to other chemicals such as polymers, aldehydes, imidoesters and anhydrides, to give enzymes more divers properties. In addition, chemists have developed a large set of reactions that label the enzymes through post-expression modifications. Many properties of an enzyme may be modified to achieve the objective:


Engineered enzymes have already showed growing use in therapeutic and industrial products. Creative Enzymes is glad to help every customer in the search of improved and optimized enzymes. Our strong technical advantage is based on a large community of biochemical scientists, who bring the latest progresses in enzymology to serve your need. You will stay with the most recent enzyme engineering technics when you choose to partner with Creative Enzymes.

Online Inquiry

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