S-adenosylmethionine synthetase, Recombinant
| Cat# | NATE-1151 |
| Abbr | MAT, Recombinant |
| Alias | MAT |
| Description | S-adenosylmethionine synthetase (EC 2.5.1.6) (also known as methionine adenosyltransferase (MAT)) is an enzyme that creates S-adenosylmethionine (AdoMet) by reacting methionine (a non-polar amino acid) and ATP (the basic currency of energy). AdoMet is a methyl donor for transmethylation. It gives away its methyl group and is also the propylamino donor in polyamine biosynthesis. S-adenosylmethionine synthetasecan be considered the rate-limiting step of the methionine cycle. |
| Appearance | White powder, lyophilized |
| Product Overview | S-adenosylmethionine (SAM) is a methyl donor and allows DNA methylation. Once DNA is methylated, it switches the genes off and therefore, S-adenosylmethionine can be considered tocontrol gene expression. SAM is also involved in gene transcription, cell proliferation, and production ofsecondary metabolites. Hence SAM synthetase is fast becoming a drug target, inparticular for the following diseases: depression, dementia, vacuolar myelopathy, liver injury, migraine, osteoarthritis, and as a potential cancer chemopreventive agent. |
| Form | Freeze dried powder |
| Enzyme Commission Number | EC 2.5.1.6 |
| Activity | >700U/mg |
| Molecular Weight | About 46kDa (SDS-PAGE detection) |
| Purity | >90% (SDS-PAGE test) |
| Isoelectric point | 4.7 |
| pH Stability | 7.0-9.5 |
| Storage | Redissolved in 30% glycerol, 4°C, store at -20°C/-80°C for long-term preservation, Avoid multiple freeze-thaw cycles. |
| Buffer | Tris buffer, pH8.0 |
| Synonyms | EC 2.5.1.6; MAT; MATA1; SAMS; SAMS1; Methionine adenosyltransferase 1; S-adenosylmethioninesynthase isoform type-1; AdoMet synthase 1; MAT 1; Methionineadenosyltransferase I/III; MAT-I/III; MAT1A; AMS1 |
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