| Cat# | NATE-1667 |
| Source | E. coli |
| Description | Cystathionine-β-synthase, also known as CBS, is an enzyme (EC 4.2.1.22) that in humans is encoded by the CBS gene. CBS uses the cofactor pyridoxal-phosphate (PLP) and can be allosterically regulated by effectors such as the ubiquitous cofactor S-adenosyl-L-methionine (adoMet). This enzyme belongs to the family of lyases, to be specific, the hydro-lyases, which cleave carbon-oxygen bonds. CBS is a multidomain enzyme composed of an N-terminal enzymatic domain and two CBS domains. The CBS gene is the most common locus for mutations associated with homocystinuria. |
| Form | Liquid |
| Activity | 100 U/mg |
| Unit Definition | One unit is defined as the amount of enzyme required to convert 1.0 nmole of L-homocysteine to cystathionine and hydrogen sulfide per minute in 200 mM Tris pH 8.6 at 37 °C. |
| Storage | Store at –20°C. |
| Synonyms | Cystathionine-β-synthase; CBS; EC 4.2.1.22; 9023-99-8; Cystathionine β-synthase; Beta-thionase; methylcysteine synthase; serine sulfhydrase |
| Enzyme Commission Number | EC 4.2.1.22 |
| Purity | > 90% by SDS-PAGE |
| Stability | Stable for at least 1 year as supplied. Avoid repeated freeze and thaw cycles. |
| Abbr | CBS, Recombinant (Human) |
| Molecular Weight | 61.9 kDa (1-551 aa, NT His Tag) |
| Species | Human |
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