| Description |
Glucose Kinase is the fourth subtype of the hexokinase family, primarily distributed in key glucose-regulating organs such as the liver, pancreas, and intestine. It functions as a glucose sensor, maintaining blood glucose homeostasis by detecting changes in glucose concentration. Its unique molecular structure and kinetic properties—including a sigmoidal activity curve and positive cooperativity—enable optimal responsiveness within the physiological glucose range, coordinating insulin secretion, hepatic glycogen synthesis, and glucagon release across multiple organs. |
