| Cat# | DIA-767 |
| Descriptions | Mannosyl-oligosaccharide 1, 2-Alpha-mannosidase IA (MAN1A1) is an endoplasmic reticulum-resident glycosidase that trims α-1,2-linked mannose residues from high-mannose N-glycans, and acts as a key processing enzyme in the early N-glycosylation maturation pathway. |
| Applications | Mannosyl-oligosaccharide 1, 2-Alpha-mannosidase IA (MAN1A1) is used for N-glycan processing detection kits and glycosylation maturation pathway assay reagent development. |
| CAS No. | 32-1-11357 |
| Enzyme Commission Number | EC 3.2.1.113 |
| Enzyme Source | Chinese Hamster Ovary cell line, CHO-derived human MAN1A1 protein. |
| Reaction | Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1, 2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2. |
| Activity Definition | Measured by its ability to remove alpha -mannose from the high mannose glycan Man-9 under the described conditions. |
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