| Cat# | DIA-772 |
| Descriptions | N-Acetylglucosaminyltransferase III (MGAT3) introduces a bisecting N-acetylglucosamine residue via β-1,4 linkage to the core β-mannose of N-glycans, modulates glycoprotein biological functions, and regulates tumor metastasis and cell adhesion properties. |
| Applications | N-Acetylglucosaminyltransferase III (MGAT3) is suitable for bisecting N-glycan detection kits and tumor metastasis related assay reagent development. |
| CAS No. | 24-1-14411 |
| Enzyme Commission Number | EC 2.4.1.144 |
| Enzyme Source | CHO-derived |
| Reaction | N4-{beta-D-GlcNAc- (1->2)-alpha-D-Man- (1->3)-[beta-D-GlcNAc- (1->2)-alpha-D-Man- (1->6)]-beta-D-Man- (1->4)-beta-D-GlcNAc- (1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H+ + N4-{beta-D-GlcNAc- (1->2)-alpha-D-Man- (1->3)-[beta-D-GlcNAc- (1->4)]-[beta-D-GlcNAc- (1->2)-alpha-D-Man- (1->6)]-beta-D-Man- (1->4)-beta-D-GlcNAc- (1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP |
| Activity Definition | Measured by its ability to transfer N-Acetyl-alpha -D-glucosamine from UDP-N-Acetyl-alpha -D-glucosamine to a biantennary N-linked core pentasaccharide in a CD39L3 coupled assay. |
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