| Cat# | DIA-769 |
| Descriptions | N-Acetylgalactosamine-6-Sulfatase (GALNS) is a lysosomal sulfatase that removes 6-sulfate groups from N-acetylgalactosamine residues in keratan sulfate and chondroitin sulfate, and its deficiency leads to mucopolysaccharidosis type IVA (Morquio A syndrome). |
| Applications | N-Acetylgalactosamine-6-Sulfatase (GALNS) serves as a core raw material for Morquio A syndrome detection kits and glycosaminoglycan metabolism assay reagent development. |
| CAS No. | 31-6-4065 |
| Enzyme Commission Number | EC 3.1.6.4 |
| Enzyme Source | Trichoplusia ni, High Five (baculovirus)-derived human N-Acetylgalactosamine-6-S. |
| Reaction | Hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate. |
| Activity Definition | Measured by its ability to hydrolyze the substrate 4-Nitrocatechol Sulfate (PNCS) under the described conditions. |
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