| Cat# | DIA-807 |
| Descriptions | Protein O-Fucosyltransferase 1 (POFUT1) specifically transfers fucose to serine/threonine residues within EGF domains of target proteins such as Notch receptors, is essential for Notch signaling pathway activation, and regulates embryonic development and cell fate determination. |
| Applications | Protein O-Fucosyltransferase 1 (POFUT1) is applied in Notch pathway glycosylation detection kits and protein O-fucosylation assay reagent development. |
| CAS No. | 24-1-22126 |
| Enzyme Commission Number | EC 2.4.1.221 |
| Enzyme Source | Trichoplusia ni, High Five (baculovirus)-derived human Protein O-Fucosyltransfer. |
| Reaction | GDP-beta-L-fucose + L-seryl-[protein] = 3-O- (alpha-L-fucosyl)-L-seryl-[protein] + GDP + H+ |
| Activity Definition | Measured by its ability to hydrolyze the donor substrate GDP-fucose. |
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