| Cat# | DIA-865 |
| Descriptions | ST3 Beta-Gal Alpha-2, 3-Sialyltransferase 6 (ST3GAL6) mainly sialylates lactosamine chains on proteoglycans and glycoproteins, mediates α-2,3 sialic acid modification of extracellular matrix components, and participates in tumor microenvironment regulation. |
| Applications | ST3 Beta-Gal Alpha-2, 3-Sialyltransferase 6 (ST3GAL6) is used for extracellular matrix sialylation detection kits and tumor microenvironment assay reagent development. |
| CAS No. | 24-9-91306 |
| Enzyme Commission Number | EC 2.4.99. |
| Enzyme Source | Chinese Hamster Ovary cell line, CHO-derived human ST3GAL6 protein. |
| Reaction | Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a alpha-2, 3-sialyltransferase activity toward Gal-beta1, 4-GlcNAc structure on glycoproteins and glycolipids. Has a restricted substrate specificity, it utilizes Gal-beta1, 4-GlcNAc on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1. |
| Activity Definition | Measured by its ability to transfer Neu5Ac from CMP-Neu5Ac to N-Acetyllactosamine. |
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