| Cat# | CAS-0905 |
| Source | E. coli |
| Description | The cytosine base editor (CBE) is a fusion of a Cas9 nickase, a deaminase, and a UGI.Deaminates C to U at the target position (window 3-12) without DSB. Creatively cages the deaminase, Active only upon sgRNA binding to the target, significantly reducing random binding, achieving near-zero off-target effects. Validated in primary NK and T cells. Ensures editing safety. |
| Storage | Dry ice shipping, -80 ± 10℃ storage, avoid freeze-thaw |
| Purity | ≥80% (SEC-HPLC) |
| Buffer | 30 mM Tris, 300 mM NaCl, 0.1 mM EDTA, 1 mM DTT, 50% Glycerol, pH 8.0 |
| Abbr | CBE |
| Applications | Single Base Editing; Induce stop codon to Knockout target gene; Mutate splice sites to Knockout target gene. |
| Appearance | Liquid |
| Molecular Weight | 210.14 kDa |
| Concentration | 10 mg/ml |
| Grade | Research Grade |
| Download Datasheet: |  |
