| Cat# | DIA-711 |
| Descriptions | Fucosyltransferase 8 (FUT8) is the only enzyme that catalyzes core α-1,6 fucosylation of N-glycans, regulates antibody-dependent cellular cytotoxicity, and is a critical target for antibody drug glycoengineering and therapeutic protein efficacy optimization. |
| Applications | Fucosyltransferase 8 (FUT8) is widely applied in antibody core fucosylation detection kits and antibody drug quality assay reagent development. |
| CAS No. | 24-1-68223 |
| Enzyme Commission Number | EC 2.4.1.68 |
| Enzyme Source | Chinese Hamster Ovary cell line, CHO-derived human Fucosyltransferase 8/FUT8 protein. |
| Reaction | GDP-beta-L-fucose + N4-{beta-D-GlcNAc- (1->2)-alpha-D-Man- (1->3)-[beta-D-GlcNAc- (1->2)-alpha-D-Man- (1->6)]-beta-D-Man- (1->4)-beta-D-GlcNAc- (1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = GDP + H+ + N4-{beta-D-GlcNAc- (1->2)-alpha-D-Man- (1->3)-[beta-D-GlcNAc- (1->2)-alpha-D-Man- (1->6)]-beta-D-Man- (1->4)-beta-D-GlcNAc- (1->4)-[alpha-L-Fuc- (1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] |
| Activity Definition | Measured by its ability to transfer fucose from GDP-fucose to N-Acetyllactosamine. |
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