| Cat# | DIA-725 |
| Descriptions | Glucosaminyl (N-acetyl) Transferase 1 (GCNT1), also known as core 2 β1,6-N-acetylglucosaminyltransferase, constructs core 2 branched O-glycan structures by adding GlcNAc to GalNAc residues, regulates mucin glycosylation, and participates in immune cell trafficking and tumor progression. |
| Applications | Glucosaminyl (N-acetyl) Transferase 1 (GCNT1) is suitable for core 2 O-glycan detection kits and immune cell trafficking assay reagent development. |
| CAS No. | 24-1-1027 |
| Enzyme Commission Number | EC 2.4.1.102 |
| Enzyme Source | Trichoplusia ni, High Five (baculovirus)-derived human Glucosaminyl (N-acetyl) T. |
| Reaction | O3-[beta-D-galactosyl- (1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{beta-D-galactosyl- (1->3)-[N-acetyl-beta-D-glucosaminyl- (1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H+ + UDP |
| Activity Definition | Measured by its ability to transfer GlcNAc from UDP-GlcNAc to B1-3 galactosyl-N-acetyl galactosamine. |
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