| Cat# | DIA-879 |
| Descriptions | Sulfamidase (SGSH) is a lysosomal sulfatase that hydrolyzes the N-sulfate groups of glucosamine residues in heparan sulfate, mediates glycosaminoglycan catabolism, and is the deficient enzyme in mucopolysaccharidosis type IIIA (Sanfilippo A syndrome). |
| Applications | Sulfamidase (SGSH) is applied in mucopolysaccharidosis type IIIA detection kits and glycosaminoglycan metabolism assay reagent development. |
| CAS No. | 31-0-1166 |
| Enzyme Commission Number | EC 3.10.1.1 |
| Enzyme Source | Trichoplusia ni, High Five (baculovirus)-derived human Sulfamidase/SGSH protein. |
| Reaction | H2O + N-sulfo-D-glucosamine = D-glucosamine + sulfate |
| Activity Definition | Measured by its ability to hydrolyze the substrate 4-Nitrocatechol Sulfate (PNCS) under the described conditions. |
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