| Cat# | DIA-887 |
| Descriptions | Tyrosylprotein Sulfotransferase 1 (TPST1) transfers sulfate groups from PAPS to tyrosine residues of secreted and membrane proteins, mediates post-translational tyrosine sulfation modification, and regulates protein-protein interactions and extracellular matrix function. |
| Applications | Tyrosylprotein Sulfotransferase 1 (TPST1) is applied in protein tyrosine sulfation detection kits and protein-protein interaction assay reagent development. |
| CAS No. | 28-02-2066 |
| Enzyme Commission Number | EC 2.8.2.20 |
| Enzyme Source | Trichoplusia ni, High Five (baculovirus)-derived human Tyrosylprotein Sulfotrans. |
| Reaction | 3′-phosphoadenylyl sulfate + L-tyrosyl-[protein] = adenosine 3′, 5′-bisphosphate + H+ + O-sulfo-L-tyrosine-[protein] |
| Activity Definition | Measured by its ability to transfer sulfate from PAPS to PSGL-1 peptide (Gln-Ala-Thr-Glu-Tyr-Glu-Tyr-Leu-Asp-Tyr-Asp-Phe-Leu-Pro-Glu-Thr) under the described conditions. |
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