UDP-glucose 6-dehydrogenase catalyzes the NAD+-dependent two-step oxidation of UDP-glucose to UDP-glucuronic acid, provides activated glucuronic acid donors for glycosaminoglycan and plant cell wall polysaccharide synthesis, and is a key enzyme for uronic acid nucleotide sugar production.
Applications
UDP-glucose 6-dehydrogenase is applied in UDP-glucuronic acid synthesis detection kits and glycosaminoglycan biosynthesis assay reagent development.