| Cat# | DIA-727 |
| Descriptions | Glucosaminyl (N-acetyl) Transferase 4 Core 2/C2GNT3 (GCNT4) is a core 2-specific glycosyltransferase isoform that synthesizes core 2 O-glycan structures with tissue-restricted expression patterns, and plays a role in mucosal barrier formation and epithelial cell glycosylation. |
| Applications | Glucosaminyl (N-acetyl) Transferase 4 Core 2/C2GNT3 (GCNT4) serves as a tool for epithelial mucin glycosylation detection kits and mucosal barrier function assay reagent development. |
| CAS No. | 24-1-1026 |
| Enzyme Commission Number | EC 2.4.1.102 |
| Enzyme Source | Chinese Hamster Ovary cell line, CHO-derived human C2GNT3/GCNT4 protein. |
| Reaction | O3-[beta-D-galactosyl- (1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{beta-D-galactosyl- (1->3)-[N-acetyl-beta-D-glucosaminyl- (1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H+ + UDP |
| Activity Definition | Measured by its ability to transfer GlcNAc from UDP-GlcNAc to B1-3 galactosyl-N-acetyl galactosamine. |
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