| Cat# | DIA-752 |
| Descriptions | Iduronate 2-Sulfatase (IDS) is a lysosomal sulfatase that removes 2-O-sulfate groups from iduronic acid residues in heparan sulfate and dermatan sulfate, mediates glycosaminoglycan degradation, and is the causative enzyme of Hunter syndrome (mucopolysaccharidosis type II). |
| Applications | Iduronate 2-Sulfatase (IDS) serves as a key raw material for Hunter syndrome detection kits and glycosaminoglycan metabolism assay reagent development. |
| CAS No. | 31-6-1364 |
| Enzyme Commission Number | EC 3.1.6.13 |
| Enzyme Source | Trichoplusia ni, High Five (baculovirus)-derived human Iduronate 2-Sulfatase/IDS protein. |
| Reaction | Hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin. |
| Activity Definition | Measured by its ability to hydrolyze the substrate 4-Nitrocatechol Sulfate (PNCS) under the described conditions. |
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